Relationships between multidrug resistance (MDR) and stem cell markers in human chronic myeloid leukemia cell lines.
نویسندگان
چکیده
The K562 cell line (chronic myeloid leukemia), sensitive to chemotherapy (non-MDR), and the Lucena cell line, resistant to chemotherapy (MDR) were investigated. The results suggest that both cell lines possess CD34+CD38- profiles of hematopoietic stem cell markers. The promoter regions of ABCB1, ABCG2 and ABCC1 genes contain binding sites for the Oct-4 transcripton factor, which is also considered a marker of tumor stem cells. Lucena cells showed an over-expression of the ABCB1 gene and a high expression of the Oct-4, ABCG2 and ABCC1 genes as compared to K562 cells.
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ورودعنوان ژورنال:
- Leukemia research
دوره 34 6 شماره
صفحات -
تاریخ انتشار 2010